Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

IL1RN

Interleukin-1 receptor antagonist protein

IL1RN ;
IL1F3 ;
IL1RA ;
Interleukin-1 receptor antagonist protein ;
IL-1RN ;
IL-1ra ;
IRAP ;
ICIL-1RA ;
IL1 inhibitor ;
Anakinra

disease:Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM:612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis.,similarity:Belongs to the IL-1 family.,tissue specificity:The intracellular form of IL1RN is predominantly expressed in epithelial cells.,

defense response, inflammatory response, immune response, response to wounding, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to corticosteroid stimulus,response to steroid hormone stimulus, response to glucocorticoid stimulus,

[Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.

The intracellular form of IL1RN is predominantly expressed in epithelial cells.