Synthesized peptide derived from human TLK1 (Phospho Ser764)

This antibody detects endogenous levels of Human TLK1 (Phospho Ser764).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SNsSG

TLK1

TLK1 (Phospho Ser764)

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Cell-cycle regulated , maximal activity in S-phase. Inactivated by phosphorylation at Ser-743 , potentially by CHK1. ,function:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23 , augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro , phosphorylates histone H3 at 'Ser-10'. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B. ,tissue specificity:Widely expressed. Present in fetal placenta , liver , kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Cell-cycle regulated , maximal activity in S-phase. Inactivated by phosphorylation at Ser-743 , potentially by CHK1. ,Function:Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23 , augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by faciliting the repair of DSBs. In vitro , phosphorylates histone H3 at 'Ser-10'. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B. ,tissue specificity:Widely expressed. Present in fetal placenta , liver , kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. ,