Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

FGF2

Fibroblast growth factor 2

FGF2 ;
FGFB ;
Fibroblast growth factor 2 ;
FGF-2 ;
Basic fibroblast growth factor ;
bFGF ;
Heparin-binding growth factor 2 ;
HBGF-2

function:The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.,miscellaneous:This protein binds heparin more strongly than does aFGF.,PTM:Several N-termini starting at positions 48, 54, 47 and 65 have been identified by direct sequencing.,sequence caution:Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.,similarity:Belongs to the heparin-binding growth factors family.,subunit:Monomer. Interacts with CSPG4 and FGFBP1. Found in a complex with FGFBP1, FGF1 and FGF2.,tissue specificity:Expressed in granulosa and cumulus cells.,

protein import into nucleus, translocation, MAPKKK cascade, activation of MAPKK activity, activation of MAPK activity,nuclear translocation of MAPK, angiogenesis, regulation of cell growth, blood vessel development, cell fate specification, induction of an organ, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, vasculature development, sprouting angiogenesis, cell migration during sprouting angiogenesis, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation, protein targeting, protein import into nucleus, steroid biosynthetic process, C21-steroid hormone biosynthetic process, phosphorus metabolic process, phosphate metabolic process,intracellular protein transport, nucleocytoplasmic transport, apoptosis, cell motion, chemotaxis, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade, small GTPase mediated signal transduction, Ras protein signal transduction, cell-cell signaling, synaptic transmission, behavior, locomotory behavior, protein localization, steroid metabolic process, C21-steroid hormone metabolic process, cell death, positive regulation of cell proliferation, negative regulation of cell proliferation, regulation of cell size, fibroblast growth factor receptor signaling pathway, lipid biosynthetic process, response to wounding, negative regulation of biosynthetic process, positive regulation of biosynthetic process, glial cell differentiation, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, regulation of endothelial cell migration, positive regulation of endothelial cell migration, negative regulation of endothelial cell migration, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression,regulation of hormone levels, regulation of cell death, programmed cell death, protein transport, regulation of striated muscle tissue development, death, phosphorylation, cell migration, negative regulation of transcription, protein import,regulation of exocytosis, regulation of calcium ion-dependent exocytosis, regulation of phosphate metabolic process,transmission of nerve impulse, regulation of granule cell precursor proliferation, positive regulation of granule cell precursor proliferation, negative regulation of cell growth, respiratory tube development, lung development,regulation of cell migration, positive regulation of cell migration, negative regulation of cell migration, developmental induction, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process,regulation of protein modification process, positive regulation of protein modification process, activation of protein kinase activity, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of cellular component size, protein localization in organelle, positive regulation of kinase activity,protein localization in nucleus, cellular protein localization, cellular hormone metabolic process, tube development,regulation of growth, regulation of locomotion, negative regulation of locomotion, positive regulation of locomotion,wound healing, gliogenesis, regulation of cell proliferation, regulation of phosphorylation, positive regulation of phosphorylation, taxis, hormone metabolic process, hormone biosynthetic process, regulation of programmed cell death, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, blood vessel endothelial cell migration, regulation of blood vessel endothelial cell migration, positive regulation of blood vessel endothelial cell migration, negative regulation of blood vessel endothelial cell migration,endothelial cell migration, regulation of kinase activity, positive regulation of molecular function, cell fate commitment,cell-cell signaling involved in cell fate specification, establishment of protein localization, regulation of transcription,positive regulation of cell differentiation, regulation of angiogenesis, positive regulation of angiogenesis, negative regulation of cell size, regulation of protein kinase activity, positive regulation of protein kinase activity, negative regulation of transcription, DNA-dependent, positive regulation of transcription, DNA-dependent, negative regulation of growth, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of organ growth, regulation of retinal cell programmed cell death, intracellular transport, blood vessel morphogenesis, regulation of muscle development, regulation of developmental growth, cell motility, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation, neurological system process, regulation of secretion, positive regulation of developmental process, nuclear transport, nuclear import, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, positive regulation of multicellular organismal process, positive regulation of protein metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of cell motion, negative regulation of cell motion, positive regulation of cell motion, regulation of cell division, regulation of transferase activity, positive regulation of transferase activity,localization of cell, positive regulation of cell division, regulation of nervous system development, regulation of cardiac muscle growth, regulation of cardiac muscle tissue development, regulation of cardiac muscle cell proliferation, positive regulation of cardiac muscle cell proliferation, regulation of cell development, regulation of cellular localization,regulation of heart growth, respiratory system development, regulation of vesicle-mediated transport, cellular macromolecule localization,

Secreted . Nucleus . Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). .

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.