Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

CTGF

Connective tissue growth factor

CTGF ;
CCN2 ;
HCS24 ;
IGFBP8 ;
Connective tissue growth factor ;
CCN family member 2 ;
Hypertrophic chondrocyte-specific protein 24 ;
Insulin-like growth factor-binding protein 8 ;
IBP-8 ;
IGF-binding protein 8 ;
IGFBP-8

function:Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Monomer.,

skeletal system development, cartilage condensation, ossification, angiogenesis, regulation of cell growth, blood vessel development, vasculature development, DNA metabolic process, DNA replication, cell motion, cell adhesion, cell-matrix adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway,transmembrane receptor protein tyrosine kinase signaling pathway, integrin-mediated signaling pathway, intracellular signaling cascade, ectoderm development, fibroblast growth factor receptor signaling pathway, epidermis development, response to wounding, cell-cell adhesion, cell migration, biological adhesion, respiratory tube development, lung development, cell-substrate adhesion, tube development, regulation of growth, blood vessel morphogenesis, skeletal system morphogenesis, cell motility, cartilage development, localization of cell, bone development, respiratory system development,

Secreted, extracellular space, extracellular matrix . Secreted .

Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.