Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

DEFB103A/DEFB103B

Beta-defensin 103

DEFB103A ;
BD3 ;
DEFB103 ;
DEFB3 ;
DEFB103B ;
Beta-defensin 103 ;
Beta-defensin 3 ;
BD-3 ;
DEFB-3 ;
HBD3 ;
hBD-3 ;
Defensin ;
beta 103 ;
Defensin-like protein

function:Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistent E.faecium. No significant hemolytic activity was observed.,induction:By infection of bacteria and by interferon gamma.,mass spectrometry: PubMed:11085990,similarity:Belongs to the beta-defensin family.,tissue specificity:Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.,

regulation of immune effector process, regulation of production of molecular mediator of immune response, regulation of antimicrobial humoral response, regulation of antimicrobial peptide production, regulation of antibacterial peptide production, regulation of antimicrobial peptide biosynthetic process, positive regulation of antimicrobial peptide biosynthetic process, regulation of antibacterial peptide biosynthetic process, regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria, regulation of response to biotic stimulus, regulation of humoral immune response, defense response, positive regulation of antibacterial peptide biosynthetic process,positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria, response to bacterium, positive regulation of biosynthetic process, positive regulation of cellular biosynthetic process, defense response to bacterium, regulation of multi-organism process,

Secreted.

Highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. Low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine.