YAP (Phospho Ser397) Rabbit pAb
-YP1554
主要信息
Target
YAP Phospho Ser397
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
67kD (Observed)
Conjugate/Modification
Phospho
货号: YP1554
规格
价格
货期
数量
200μL
￥4,680.00
一个月
0
100μL
￥2,800.00
一个月
0
50μL
￥1,500.00
一个月
0
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详细信息
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
67kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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KA3612C
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human YAP (Ser397)
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特异性:
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
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基因名称:
YAP1 YAP65
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蛋白名称:
Transcriptional coactivator YAP1
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别名:
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65 ;
65 kDa Yes-associated protein ;
YAP65 ;
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背景:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development , growth , repair , and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Aug 2013] ,
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功能:
PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Contains 1 WW domain. ,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds , in vitro , through the WW1 domain , to neural isoforms of ENAH that contain the PPSY motif. ,
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细胞定位:
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288 , PubMed:20048001) . Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288 , PubMed:20048001) . At low density , predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288 , PubMed:20048001 , PubMed:25849865) . PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271) . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) . .
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研究领域:
>>Hippo signaling pathway ;
>>Hippo signaling pathway - multiple species
>>Hippo signaling pathway - multiple species
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信号通路
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货号: YP1554
规格
价格
货期
数量
200μL
￥4,680.00
一个月
0
100μL
￥2,800.00
一个月
0
50μL
￥1,500.00
一个月
0
加入购物车
已收藏
收藏
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