TPOR (Phospho Tyr626) Rabbit pAb
-YP1535
主要信息
Target
TPOR Phospho Tyr626
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
69,40kD (Observed)
Conjugate/Modification
Phospho
货号: YP1535
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human TPOR (phospho-Tyr626)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
69,40kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human TPOR (Tyr626)
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特异性:
This antibody detects endogenous levels of Human TPOR (phospho-Tyr626)
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基因名称:
MPL TPOR
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蛋白名称:
Thrombopoietin receptor (Tyr626)
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别名:
MPL ;
TPOR ;
Thrombopoietin receptor ;
TPO-R ;
Myeloproliferative leukemia protein ;
Proto-oncogene c-Mpl ;
CD110
TPOR ;
Thrombopoietin receptor ;
TPO-R ;
Myeloproliferative leukemia protein ;
Proto-oncogene c-Mpl ;
CD110
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背景:
In 1990 an oncogene , v-mpl , was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue , named , c-mpl , was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl , thrombopoietin , was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene , CD110 , is a 635 amino acid transmembrane domain , with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic , emphasizing the important
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功能:
Caution:It is uncertain whether Met-1 or Met-8 is the initiator. ,Disease:Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies. ,Domain:The box 1 motif is required for JAK interaction and/or activation. ,Domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. ,Function:Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses. ,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily. ,similarity:Contains 2 fibronectin type-III domains. ,subunit:Interacts with ATXN2L. ,tissue specificity:Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed. ,
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细胞定位:
Cell membrane ; Single-pass type I membrane protein. Golgi apparatus . Cell surface .
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研究领域:
>>Cytokine-cytokine receptor interaction ;
>>JAK-STAT signaling pathway
>>JAK-STAT signaling pathway
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信号通路
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货号: YP1535
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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