SOX-2 (Phospho Ser250/251) Rabbit pAb
-YP1503
主要信息
Target
SOX-2 Phospho Ser250/251
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC
MW
35kD (Observed)
Conjugate/Modification
Phospho
货号: YP1503
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of SOX-2 only when phosphorylated at Ser250/Ser251,and dually phosphorylated at two sites.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
35kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human Sox2 (Ser250 and Ser251)
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特异性:
This antibody detects endogenous levels of SOX-2 only when phosphorylated at Ser250/Ser251,and dually phosphorylated at two sites.
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基因名称:
SOX2
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蛋白名称:
Sox2 (Ser250/Ser251)
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别名:
SOX2 ;
Transcription factor SOX-2
Transcription factor SOX-2
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背景:
SRY-box 2 (SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system , and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia , a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT) . [provided by RefSeq , Jul 2008] ,
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功能:
Disease:Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. Microphthalmia is a clinically heterogeneous disorder of eye formation , ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia) . In many cases , microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS3 is characterized by the rare association of malformations including uni- or bilateral anophthalmia or microphthalmia , and esophageal atresia with trachoesophageal fistula. ,Function:Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1 , FGF4 , UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. ,online information:Sox2 entry ,PTM:Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation. ,similarity:Contains 1 HMG box DNA-binding domain. ,
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细胞定位:
Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity) . Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) . Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity) . Nuclear import is facilitated by XPO4 , a protein that usually acts as a nuclear export signal receptor (By similarity) . .
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组织表达:
研究领域:
>>Hippo signaling pathway ;
>>Signaling pathways regulating pluripotency of stem cells
>>Signaling pathways regulating pluripotency of stem cells
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信号通路
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货号: YP1503
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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