SIN1 (Phospho Thr86) Rabbit pAb
-YP1494
主要信息
Target
SIN1 Phospho Thr86
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA, IHC
MW
58kD (Observed)
Conjugate/Modification
Phospho
货号: YP1494
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human Mouse Sin1 (phospho-Thr86)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
58kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
抗原&靶点信息
免疫原:
Synthesized phosho peptide around human Sin1 (Thr86)
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特异性:
This antibody detects endogenous levels of Human Mouse Sin1 (phospho-Thr86)
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基因名称:
MAPKAP1 MIP1 SIN1
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蛋白名称:
Target of rapamycin complex 2 subunit MAPKAP1
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别名:
Target of rapamycin complex 2 subunit MAPKAP1 ;
TORC2 subunit MAPKAP1 ;
Mitogen-activated protein kinase 2-associated protein 1 ;
Stress-activated map kinase-interacting protein 1 ;
SAPK-interacting protein 1 ;
mSIN1 ;
TORC2 subunit MAPKAP1 ;
Mitogen-activated protein kinase 2-associated protein 1 ;
Stress-activated map kinase-interacting protein 1 ;
SAPK-interacting protein 1 ;
mSIN1 ;
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背景:
This gene encodes a protein that is highly similar to the yeast SIN1 protein , a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq , Jul 2008] ,
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功能:
Function:Essential component of the TORC2 complex , which plays a critical role in AKT1 'Ser-473' phosphorylation , and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization. Inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAs signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. ,similarity:Belongs to the SIN1 family. ,subunit:All isoforms except isoform 4 are able to be part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1 , LST8 , PROTOR1 , RICTOR and MAPKAP1. Interacts with ATF2 , MAP3K2 and MAPK8. Interacts with GTP-bound HRAS and KRAS. Interacts with IFNAR2. ,tissue specificity:Ubiquitously expressed , with highest levels in heart and skeletal muscle. ,
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细胞定位:
Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
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研究领域:
>>mTOR signaling pathway
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文献引用（{{totalcount}}）
货号: YP1494
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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