SGK3 (Phospho Thr320) Rabbit pAb
-YP1486
主要信息
Target
SGK3 Phospho Thr320
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
54kD (Observed)
Conjugate/Modification
Phospho
货号: YP1486
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human SGK3 (phospho-Thr320)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
54kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human SGK3 (Thr320)
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特异性:
This antibody detects endogenous levels of Human SGK3 (phospho-Thr320)
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基因名称:
SGK3 CISK SGKL
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蛋白名称:
Serine/threonine-protein kinase Sgk3
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别名:
Serine/threonine-protein kinase Sgk3 ;
Cytokine-independent survival kinase ;
Serum/glucocorticoid-regulated kinase 3 ;
Serum/glucocorticoid-regulated kinase-like ;
Cytokine-independent survival kinase ;
Serum/glucocorticoid-regulated kinase 3 ;
Serum/glucocorticoid-regulated kinase-like ;
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背景:
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants , encoding different isoforms , have been characterized. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Two specific sites , one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486) , need to be phosphorylated for its full activation. ,Function:Involved in the activation of potassium channels. Mediates cell IL-3-dependent survival signals. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 PX (phox homology) domain. ,subcellular location:Localized in vesicle-like structures and in the early endosome. ,tissue specificity:Expressed in most tissues with highest levels in pancreas , kidney liver , heart and brain and lower levels in lung , placenta and skeletal muscle. ,
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细胞定位:
Cytoplasmic vesicle . Early endosome. Recycling endosome. Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
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研究领域:
>>FoxO signaling pathway ;
>>PI3K-Akt signaling pathway
>>PI3K-Akt signaling pathway
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信号通路
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货号: YP1486
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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