Synthesized phosho peptide around human SEK1 (Ser257 and Thr261)

This antibody detects endogenous levels of MEK-4 only when phosphorylated at Ser257/Thr261,and dually phosphorylated at two sites.

MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1

SEK1/MKK4 (Ser257/Thr261)

Dual specificity mitogen-activated protein kinase kinase 4 ;
MAP kinase kinase 4 ;
MAPKK 4 ;
JNK-activating kinase 1 ;
MAPK/ERK kinase 4 ;
MEK 4 ;
SAPK/ERK kinase 1 ;
SEK1 ;
Stress-activated protein kinase kinase 1 ;
SAPK kinase 1 ;
SAPKK-1 ;
SAPKK1 ;
c-Jun N-terminal kinase kinase 1 ;
JNKK ;

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation , differentiation , transcription regulation , and development. They form a three-tiered signaling module composed of MAPKKKs , MAPKKs , and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Jul 2013] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1) . ,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with SPAG9. ,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues. ,

Cytoplasm . Nucleus .

>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Toll-like receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>TNF signaling pathway ;
>>GnRH signaling pathway ;
>>Relaxin signaling pathway ;
>>Growth hormone synthesis , secretion and action ;
>>Alcoholic liver disease ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Salmonella infection ;
>>Yersinia infection ;
>>Chagas disease ;
>>Hepatitis B ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis