Function:Required for DNA recombination , repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. ,PTM:Phosphorylated in a cell-cycle-dependent manner (from the S phase until mitosis) . Phosphorylated by ATR upon DNA damage , which promotes its translocation to nuclear foci. Can be phosphorylated in vitro by PRKDC/DNA-PK in the presence of Ku and DNA , and by CDC2. ,subcellular location:Also present in PML nuclear bodies. Redistributes to discrete nuclear foci upon DNA damage. ,subunit:Heterotrimer of 70 , 32 and 14 kDa chains. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN. ,
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