ROS1 (Phospho Tyr2274) Rabbit pAb
-YP1469
主要信息
Target
ROS1 Phospho Tyr2274
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF
MW
258kD (Observed)
Conjugate/Modification
Phospho
货号: YP1469
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human ROS1 (phospho-Tyr2274).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LNyMV
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
258kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human ROS1 (Tyr2274)
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特异性:
This antibody detects endogenous levels of Human ROS1 (phospho-Tyr2274).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LNyMV
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基因名称:
ROS1 MCF3 ROS
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蛋白名称:
ROS1 (Tyr2274)
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别名:
Proto-oncogene tyrosine-protein kinase ROS ;
Proto-oncogene c-Ros ;
Proto-oncogene c-Ros-1 ;
Receptor tyrosine kinase c-ros oncogene 1 ;
c-Ros receptor tyrosine kinase ;
Proto-oncogene c-Ros ;
Proto-oncogene c-Ros-1 ;
Receptor tyrosine kinase c-ros oncogene 1 ;
c-Ros receptor tyrosine kinase ;
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背景:
This proto-oncogene , highly-expressed in a variety of tumor cell lines , belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM) . An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity. ,Function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 9 fibronectin type-III domains. ,
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细胞定位:
Cell membrane ; Single-pass type I membrane protein .
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文献引用（{{totalcount}}）
货号: YP1469
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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