Synthesized phosho peptide around human PZR (Tyr263)

This antibody detects endogenous levels of Human Mouse Rat PZR (phospho-Tyr263)

MPZL1 PZR UNQ849/PRO1787

PZR (Tyr263)

Myelin protein zero-like protein 1 ;
Protein zero-related ;

Domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) . This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. ,Function:Cell surface receptor , which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin A (ConA) and is involved in cellular signaling induced by ConA , which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1 , but not isoform 2 and isoform 3 , may be involved in regulation of integrin-mediated cell motility. ,PTM:N-glycosylated. ,PTM:Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin A (ConA) . Phosphorylation at Tyr-241 and Tyr-263 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) . ,similarity:Belongs to the myelin P0 protein family. ,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain. ,subunit:Interacts with phosphorylated PTPN11/SHP-2. ,tissue specificity:Widely expressed with highest levels in heart , placenta , kidney and pancreas. Isoform 3 is relatively abundant in hemotopoietic tissues and fetal liver. Isoform 1 and isoform 3 are expressed in CD14- PB monocytes and pre-B cell progenitors. Isoform 3 appears to be the major isoform in CD34- promyelocytic and promonocytic cells. During differentiation in monocytic cells , the expression level of isoform 3 decreases and that of isoform 1 increases. Isoform 1 is prominent in stromal cells and , to a lesser extent , in umbelical vein endothelial cells and erythroid progenitors. Isoform 2 is expressed in a erythroid progenitor cell line. ,

Membrane ; Single-pass type I membrane protein .

>>Cell adhesion molecules