PRAS40 (Phospho Ser183) Rabbit pAb
-YP1449
主要信息
Target
PRAS40 Phospho Ser183
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA, IHC
MW
40kD (Observed)
Conjugate/Modification
Phospho
货号: YP1449
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human Mouse PRAS40 (phospho-Ser183)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
40kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
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ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human PRAS40 (Ser183)
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特异性:
This antibody detects endogenous levels of Human Mouse PRAS40 (phospho-Ser183)
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基因名称:
AKT1S1 PRAS40
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蛋白名称:
PRAS40 (Ser183)
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别名:
AKT1S1 ;
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
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背景:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH , MIM 113508) when phosphorylated (Kovacina et al. , 2003 [PubMed 12524439]) .[supplied by OMIM , Mar 2008] ,
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功能:
Function:May play an important role in phosphatidylinositol 3-kinase (PI3K) -AKT1 survival signaling. Substrate for AKT1 phosphorylation , but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection. ,subcellular location:Found in the cytosolic fraction of the brain. ,subunit:The phosphorylated form interacts with 14-3-3. ,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293) . ,
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细胞定位:
Cytoplasm , cytosol . Found in the cytosolic fraction of the brain. .
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研究领域:
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Thermogenesis ;
>>Shigellosis
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Thermogenesis ;
>>Shigellosis
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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货号: YP1449
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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