Synthesized phosho peptide around human PPIG (Ser376)

This antibody detects endogenous levels of Human Mouse Rat PPIG (phospho-Ser376).The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VSsGE

PPIG

PPIG (Ser376)

Peptidyl-prolyl cis-trans isomerase G ;
PPIase G ;
Peptidyl-prolyl isomerase G ;
CASP10 ;
Clk-associating RS-cyclophilin ;
CARS-Cyp ;
CARS-cyclophilin ;
SR-cyclophilin ;
SR-cyp ;
SRcyp ;
Cyclophilin G ;
Rotamase G ;

Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0) . ,Domain:The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II. ,enzyme regulation:Cyclosporin A (CsA) -sensitive. ,Function:PPIases accelerate the folding of proteins. ,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. ,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding , transport , and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the cyclophilin-type PPIase family. ,similarity:Contains 1 PPIase cyclophilin-type domain. ,subcellular location:Colocalizes with RNA splicing factors at nuclear speckles. ,subunit:Interacts with CLK1 , PNN and with the phosphorylated C-terminal domain of RNA polymerase II. ,tissue specificity:Ubiquitous. ,

Nucleus matrix . Nucleus speckle . Colocalizes with RNA splicing factors at nuclear speckles. .