PNK1 (Phospho Ser114/Thr118) Rabbit pAb
-YP1447
主要信息
Target
PNK1 Phospho Ser114/Thr118
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
57kD (Observed)
Conjugate/Modification
Phospho
货号: YP1447
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of PNK1 only when phosphorylated at Ser114 or Thr118,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PEsQP
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
57kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human PNK1 (Ser114 and Thr118)
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特异性:
This antibody detects endogenous levels of PNK1 only when phosphorylated at Ser114 or Thr118,and dually phosphorylated at two sites.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PEsQP
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基因名称:
PNKP
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蛋白名称:
PNK1 (Ser114/Thr118)
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别名:
Bifunctional polynucleotide phosphatase/kinase ;
DNA 5'-kinase/3'-phosphatase ;
Polynucleotide kinase-3'-phosphatase ;
[Includes: Polynucleotide 3'-phosphatase ;
2' ;
3' ;
-polynucleotidase ;
Polynucleotide 5'-hydroxyl-kinase ;
]
DNA 5'-kinase/3'-phosphatase ;
Polynucleotide kinase-3'-phosphatase ;
[Includes: Polynucleotide 3'-phosphatase ;
2' ;
3' ;
-polynucleotidase ;
Polynucleotide 5'-hydroxyl-kinase ;
]
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背景:
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage , the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly , seizures , and developmental delay.[provided by RefSeq , Sep 2010] ,
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功能:
Catalytic activity:A 3'-phosphopolynucleotide + H (2) O = a polynucleotide + phosphate. ,Catalytic activity:ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA. ,Function:Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Plays an important function in DNA repair following ionizing radiation or oxidative damage. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:In the N-terminal section; belongs to the DNA 3' phosphatase family. ,tissue specificity:Expressed in many tissues with highest expression in spleen and testis , and lowest expression in small intestine (PubMed:10446192) . Expressed in higher amount in pancreas , heart and kidney and at lower levels in brain , lung and liver (PubMed:10446193) . ,
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细胞定位:
Nucleus . Chromosome . Localizes to site of double-strand breaks. .
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文献引用（{{totalcount}}）
货号: YP1447
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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