Synthesized phosho peptide around human PKCα (Thr638 and 641)

This antibody detects endogenous levels of PKCα/β II only when phosphorylated at Thr638/641.This antibody does not recognize phosphorylated at other sites.

PKCα/β II (Thr638/641)

Protein kinase C alpha type ;
PKC-A ;
PKC-alpha ;

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters , a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes , such as cell adhesion , cell transformation , cell cycle checkpoint , and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca (2+) handling in myocytes. [provided by RefSeq , Jul 2

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Binds 3 calcium ions per subunit. The ions are bound to the C2 domain. ,Function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters , a class of tumor promoters. ,Function:This is a calcium-activated , phospholipid-dependent , serine- and threonine-specific enzyme. May play a role in cell motility by phosphorylating CSPG4. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 C2 domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers. ,subunit:Interacts with ADAP1/CENTA1 , CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine. ,

Cytoplasm . Cell membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Nucleus .

>>EGFR tyrosine kinase inhibitor resistance ;
>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>HIF-1 signaling pathway ;
>>Phosphatidylinositol signaling system ;
>>Sphingolipid signaling pathway ;
>>Phospholipase D signaling pathway ;
>>mTOR signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Adrenergic signaling in cardiomyocytes ;
>>Vascular smooth muscle contraction ;
>>Wnt signaling pathway ;
>>Axon guidance ;
>>VEGF signaling pathway ;
>>Focal adhesion ;
>>Gap junction ;
>>Neutrophil extracellular trap formation ;
>>Natural killer cell mediated cytotoxicity ;
>>Fc epsilon RI signaling pathway ;
>>Fc gamma R-mediated phagocytosis ;
>>Leukocyte transendothelial migration ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Cholinergic synapse ;
>>Serotonergic synapse ;
>>GABAergic synapse ;
>>Dopaminergic synapse ;
>>Long-term depression ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Melanogenesis ;
>>Thyroid hormone synthesis ;
>>Thyroid hormone signaling pathway ;
>>Oxytocin signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Relaxin signaling pathway ;
>>Parathyroid hormone synthesis , secretion and action ;
>>GnRH secretion ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Growth hormone synthesis , secretion and action ;
>>Aldosterone-regulated sodium reabsorption ;
>>Endocrine and other factor-regulated calcium reabsorption ;
>>Salivary secretion ;
>>Gastric acid secretion ;
>>Pancreatic secretion ;
>>Spinocerebellar ataxia ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Amphetamine addiction ;
>>Morphine addiction ;
>>Vibrio cholerae infection ;
>>African trypanosomiasis ;
>>Amoebiasis ;
>>Hepatitis B ;
>>Human cytomegalovirus infection ;
>>Influenza A ;
>>Human immunodeficiency virus 1 infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Glioma ;
>>Non-small cell lung cancer ;
>>Hepatocellular carcinoma ;
>>Choline metabolism in cancer ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis