Synthesized phosho peptide around human PDGF Receptor β (Tyr1009)

This antibody detects endogenous levels of Human Mouse PDGF Receptor β (phospho-Tyr1009) .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VLyTA

PDGFRB PDGFR PDGFR1

Platelet-derived growth factor receptor beta

PDGFRB ;
PDGFR ;
PDGFR1 ;
Platelet-derived growth factor receptor beta ;
PDGF-R-beta ;
PDGFR-beta ;
Beta platelet-derived growth factor receptor ;
Beta-type platelet-derived growth factor receptor ;
CD140 antigen-like family member B ;
Platelet-deri

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer , composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development , wound healing , and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome , somatic and familial gastrointestinal stromal tumors , and a variety of other cancers. [provided by RefSeq , Mar 2012] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Disease:A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA) , due to an interstitial chromosomal deletion , is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow , eosinophilia , tissue infiltration and organ damage. ,Function:Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains. ,subunit:Homodimer , and heterodimer with PDGFRB. Interacts with the SH2 domain of SHB via phosphorylated Tyr-720 (By similarity) . Interacts with the SH2 domain of SHF via phosphorylated Tyr-720. ,tissue specificity:Expressed in primary and metastatic colon tumors and in normal colon tissue. Tumors may express a different isoform to that found in normal tissue. ,

Cell membrane ; Single-pass type I membrane protein . Cell projection , cilium . Golgi apparatus .

>>EGFR tyrosine kinase inhibitor resistance ;
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>Gap junction ;
>>JAK-STAT signaling pathway ;
>>Regulation of actin cytoskeleton ;
>>Human cytomegalovirus infection ;
>>Pathways in cancer ;
>>MicroRNAs in cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Central carbon metabolism in cancer ;
>>Choline metabolism in cancer