p56 Dok-2 (Phospho Tyr351) Rabbit pAb
-YP1425
主要信息
Target
Dok 2 Phospho Tyr351
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
48kD (Observed)
Conjugate/Modification
Phospho
货号: YP1425
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human p56Dok-2 (phospho-Tyr351)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
48kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human p56Dok-2 (Tyr351)
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特异性:
This antibody detects endogenous levels of Human p56Dok-2 (phospho-Tyr351)
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基因名称:
DOK2
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蛋白名称:
p56Dok-2 (Tyr351)
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别名:
Docking protein 2 ;
Downstream of tyrosine kinase 2 ;
p56 ;
dok-2 ;
Downstream of tyrosine kinase 2 ;
p56 ;
dok-2 ;
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背景:
docking protein 2 (DOK2) Homo sapiens The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl) , a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq , Jul 2008] ,
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功能:
Domain:PTB domain mediates receptor interaction. ,Function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4 , as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. ,PTM:On immunoreceptor stimulation , phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. ,similarity:Belongs to the DOK family. Type A subfamily. ,similarity:Contains 1 IRS-type PTB domain. ,similarity:Contains 1 PH domain. ,subunit:Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. ,tissue specificity:Highly expressed in peripheral blood leukocytes , lymph nodes and spleen. Lower expression in thymus , bone marrow and fetal liver. ,
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细胞定位:
cytosol ,
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货号: YP1425
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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