MCM2 (Phospho Ser139) Rabbit pAb
-YP1397
主要信息
Target
MCM2 Phospho Ser139
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
120kD (Observed)
Conjugate/Modification
Phospho
货号: YP1397
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human Mouse Rat MCM2 (phospho-Ser139) .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YDsDE
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
120kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human MCM2 (Ser139)
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特异性:
This antibody detects endogenous levels of Human Mouse Rat MCM2 (phospho-Ser139) .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YDsDE
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基因名称:
MCM2 BM28 CCNL1 CDCL1 KIAA0030
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蛋白名称:
MCM2 (Ser139)
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别名:
MCM2 ;
BM28 ;
CCNL1 ;
CDCL1 ;
KIAA0030 ;
DNA replication licensing factor MCM2 ;
Minichromosome maintenance protein 2 homolog ;
Nuclear protein BM28
BM28 ;
CCNL1 ;
CDCL1 ;
KIAA0030 ;
DNA replication licensing factor MCM2 ;
Minichromosome maintenance protein 2 homolog ;
Nuclear protein BM28
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背景:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4 , 6 , and 7 , and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated , and thus regulated by , protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found , but the full-length nature of some variants has not been defined. [provided by RefSeq , Oct 2012] ,
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功能:
Function:Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. ,PTM:Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes , while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. ,sequence Caution:Translation N-terminally shortened. ,similarity:Belongs to the MCM family. ,similarity:Contains 1 MCM domain. ,subunit:Interacts with DBF4 (By similarity) . Interacts with MYST2. May interact with MCM10. ,
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细胞定位:
Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
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研究领域:
>>DNA replication ;
>>Cell cycle
>>Cell cycle
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文献引用（{{totalcount}}）
货号: YP1397
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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