Synthesized phosho peptide around human LSD1 (Ser131)

This antibody detects endogenous levels of Human LSD1 (phospho-Ser131)

KDM1A AOF2 KDM1 KIAA0601 LSD1

LSD1 (Ser131)

KDM1A ;
AOF2 ;
KDM1 ;
KIAA0601 ;
LSD1 ;
Lysine-specific histone demethylase 1A ;
BRAF35-HDAC complex protein BHC110 ;
Flavin-containing amine oxidase domain-containing protein 2

This gene encodes a nuclear protein containing a SWIRM domain , a FAD-binding motif , and an amine oxidase domain. This protein is a component of several histone deacetylase complexes , though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Apr 2009] ,

cofactor:FAD. ,Domain:The SWIRN domain may act as an anchor site for a histone tail. ,Function:Histone demethylase that demethylates 'Lys-4' of histone H3 , a specific tag for epigenetic transcriptional activation , thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. May play a role in the repression of neuronal genes. Alone , it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. May also demethylate 'Lys-9' of histone H3 , a specific tag for epigenetic transcriptional repression , thereby leading to derepression of androgen receptor target genes. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. ,similarity:Belongs to the flavin monoamine oxidase family. ,similarity:Contains 1 SWIRM domain. ,subunit:Component of a BHC histone deacetylase complex that contains HDAC1 , HDAC2 , HMG20B/BRAF35 , KDM1 , RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2 , ZNF217 , ZMYM3 , GSE1 and GTF2I. In the complex , RCOR1/CoREST strongly enhances the demethylase activity and protects it from the proteasome while PHF21A/BHC80 inhibits the demethylase activity. Interacts with the androgen receptor (AR) . ,tissue specificity:Ubiquitously expressed. ,

Nucleus .

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