MARCKS (Phospho Ser159/163) Rabbit pAb
-YP1392
主要信息
Target
MARCKS Phospho Ser159/163
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
32kD (Observed)
Conjugate/Modification
Phospho
货号: YP1392
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser159 or Ser163,and dually phosphorylated at two sites.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
32kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human MARCKS (Ser159 and 163)
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特异性:
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser159 or Ser163,and dually phosphorylated at two sites.
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基因名称:
MARCKS MACS PRKCSL
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蛋白名称:
MARCKS (Ser159/163)
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别名:
Myristoylated alanine-rich C-kinase substrate ;
MARCKS ;
Protein kinase C substrate,80 kDa protein,light chain ;
80K-L protein ;
PKCSL ;
MARCKS ;
Protein kinase C substrate,80 kDa protein,light chain ;
80K-L protein ;
PKCSL ;
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背景:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane , leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility , phagocytosis , membrane trafficking and mitogenesis. [provided by RefSeq , Jul 2008] ,
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功能:
Function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin , actin , and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. ,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. ,similarity:Belongs to the MARCKS family. ,
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细胞定位:
Cytoplasm , cytoskeleton . Membrane ; Lipid-anchor .
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组织表达:
研究领域:
>>Fc gamma R-mediated phagocytosis ;
>>MicroRNAs in cancer
>>MicroRNAs in cancer
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信号通路
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货号: YP1392
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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