Synthesized phosho peptide around human IKKε (Ser172)

This antibody detects endogenous levels of Human IKKε (phospho-Ser172) .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):FVsVY

IKBKE IKKE IKKI KIAA0151

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

IKBKE ;
IKKE ;
IKKI ;
KIAA0151 ;
Inhibitor of nuclear factor kappa-B kinase subunit epsilon ;
I-kappa-B kinase epsilon ;
IKK-E ;
IKK-epsilon ;
IkBKE ;
Inducible I kappa-B kinase ;
IKK-i

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al. , 2009 [PubMed 19481526]) .[supplied by OMIM , Oct 2009] ,

Catalytic activity:ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein]. ,Function:Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. ,PTM:Autophosphorylated. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF , IRF3 and DDX58/RIG-I , interactions are disrupted by the interaction between IKBKE and SIKE. ,tissue specificity:Highly expressed in spleen followed by thymus , peripheral blood leukocytes , pancreas , placenta. Weakly expressed in lung , kidney , prostate , ovary and colon. ,

Cytoplasm . Nucleus. Nucleus , PML body . Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669) . Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218) . .

>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Alcoholic liver disease ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Coronavirus disease - COVID-19 ;
>>Chemical carcinogenesis - receptor activation ;
>>Lipid and atherosclerosis