Synthesized phosho peptide around human FoxM1 (Thr600)

This antibody detects endogenous levels of Human FoxM1 (phospho-Thr600)

FOXM1 FKHL16 HFH11 MPP2 WIN

Forkhead box protein M1 (Thr600)

Forkhead box protein M1 ;
Forkhead-related protein FKHL16 ;
Hepatocyte nuclear factor 3 forkhead homolog 11 ;
HFH-11 ;
HNF-3/fork-head homolog 11 ;
M-phase phosphoprotein 2 ;
MPM-2 reactive phosphoprotein 2 ;
Transcription factor Trident ;
Winged-helix factor from INS-1 cells ;

The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes , such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2011] ,

Alternative products:Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3 , found in rat , does not seem to exist in human ,developmental stage:Embryonic expression pattern: liver , lung , intestine , kidney , urinary tract; adult expression pattern: intestine , colon , testis and thymus. ,Domain:Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity , as it is the case for isoform 4. ,Function:Transcriptional activatory factor. May play a role in the control of cell proliferation. ,induction:Induced during liver regeneration and oxidative stress. ,PTM:Phosphorylated in M (mitotic) phase. ,similarity:Contains 1 fork-head DNA-binding domain. ,tissue specificity:Expressed in thymus , testis , small intestine , colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. ,

Nucleus.

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