Synthesized phosho peptide around human DDR1 (Tyr792)

This antibody detects endogenous levels of Human DDR1 (phospho-Tyr792)

DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE

DDR1 (Tyr792)

Epithelial discoidin domain-containing receptor 1 ;
Epithelial discoidin domain receptor 1 ;
CD167 antigen-like family member A ;
Cell adhesion kinase ;
Discoidin receptor tyrosine kinase ;
HGK2 ;
Mammary carcinoma kinase 10 ;
MCK-10 ;
Protein-tyrosine kinase 3A ;
Protein-tyrosine kinase RTK-6 ;
TRK E ;
Tyrosine kinase DDR ;
Tyrosine-protein kinase CAK ;
CD antigen CD167a ;

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth , differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain , and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells , particularly in the kidney , lung , gastrointestinal tract , and brain. In addition , it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq , Feb 2011] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Domain:The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates. ,Function:May be involved in cell-cell interactions and recognition. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. ,similarity:Contains 1 F5/8 type C domain. ,similarity:Contains 1 protein kinase domain. ,tissue specificity:Expressed at low levels in most adult tissues and is highest in the brain and lung. Abundant in breast carcinoma cell lines. ,

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted .; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.