Synthesized phosho peptide around human Bim (Ser77)

This antibody detects endogenous levels of Human Mouse Bim (phospho-Ser77)

BCL2L11 BIM

Bim (Ser77)

Bcl-2-like protein 11 ;
Bcl2-L-11 ;
Bcl2-interacting mediator of cell death ;

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3) . It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF) , as well as by the forkhead transcription factor FKHR-L1 , which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq , Jun 2013] ,

Domain:The BH3 motif is required for Bcl-2 binding and cytotoxicity. ,Function:Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1 , isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis , although less potent than the isoforms BimEL , BimL and BimS. Isoform Bim-gamma induces apoptosis. ,similarity:Belongs to the Bcl-2 family. ,subcellular location:Associated with intracytoplasmic membranes. ,subunit:Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1 , BCL2 , BCL2L1 isoform Bcl-X (L) , BCL2A1/BFL-1 , and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD , BOK , BAX or BAK. ,tissue specificity:Isoform BimEL , isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon , and in lower levels in spleen , prostate , testis , heart , liver and kidney. ,

Endomembrane system ; Peripheral membrane protein . Associated with intracytoplasmic membranes. .; [Isoform BimEL]: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.; [Isoform BimL]: Mitochondrion.; [Isoform BimS]: Mitochondrion.; [Isoform Bim-alpha1]: Mitochondrion.

>>EGFR tyrosine kinase inhibitor resistance ;
>>FoxO signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Apoptosis ;
>>Apoptosis - multiple species ;
>>Non-alcoholic fatty liver disease ;
>>Epstein-Barr virus infection ;
>>Pathways in cancer ;
>>MicroRNAs in cancer ;
>>Colorectal cancer