RanBP3 (Phospho Ser58) Rabbit pAb
-YP1460
主要信息
Target
RanBP3 Phospho Ser58
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA, IHC
MW
60kD (Observed)
Conjugate/Modification
Phospho
货号: YP1460
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human RanBP3 (phospho-Ser58)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
60kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
抗原&靶点信息
免疫原:
Synthesized phosho peptide around human RanBP3 (Ser58)
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特异性:
This antibody detects endogenous levels of Human RanBP3 (phospho-Ser58)
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基因名称:
RANBP3
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蛋白名称:
Ran-binding protein 3
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别名:
RANB3 ;
Ran-binding protein 3 ;
RanBP3 ;
Ran-binding protein 3 ;
RanBP3 ;
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背景:
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
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功能:
Function:Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RanBD1 domain.,subunit:Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1.,tissue specificity:Widely expressed with high levels in testis and heart.,
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细胞定位:
Cytoplasm . Nucleus .
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研究领域:
>>Human T-cell leukemia virus 1 infection
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文献引用（{{totalcount}}）
货号: YP1460
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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