Rad18 (Phospho Ser403) Rabbit pAb
-YP1458
主要信息
Target
Rad18 Phospho Ser403
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA, IHC
MW
56kD (Observed)
Conjugate/Modification
Phospho
货号: YP1458
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of Human Rad18 (phospho-Ser403)
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
56kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human Rad18 (Ser403)
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特异性:
This antibody detects endogenous levels of Human Rad18 (phospho-Ser403)
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基因名称:
RAD18 RNF73
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蛋白名称:
E3 ubiquitin-protein ligase RAD18
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别名:
RAD18 ;
RNF73 ;
E3 ubiquitin-protein ligase RAD18 ;
Postreplication repair protein RAD18 ;
hHR18 ;
hRAD18 ;
RING finger protein 73
RNF73 ;
E3 ubiquitin-protein ligase RAD18 ;
Postreplication repair protein RAD18 ;
hHR18 ;
hRAD18 ;
RING finger protein 73
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背景:
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008],
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功能:
Function:E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the RAD18 family.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 1 SAP domain.,subunit:Interacts with UBE2A and UBE2B. Interacts with SHPRH.,
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细胞定位:
Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). .
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组织表达:
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货号: YP1458
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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