Synthesized phosho peptide around human MKK-7 (Ser271 and Thr275)

This antibody detects endogenous levels of MKK-7 only when phosphorylated at Ser271 or Thr275,and dually phosphorylated at two sites.

MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4

MKK7 (Ser271/Thr275)

Dual specificity mitogen-activated protein kinase kinase 7 ;
MAP kinase kinase 7 ;
MAPKK 7 ;
JNK-activating kinase 2 ;
MAPK/ERK kinase 7 ;
MEK 7 ;
Stress-activated protein kinase kinase 4 ;
SAPK kinase 4 ;
SAPKK-4 ;
SAPKK4 ;
c-Jun N-terminal kinase kinase 2 ;
JNK kinase 2 ;
JNKK 2 ;

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,Function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.,

Nucleus. Cytoplasm .

>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Protein processing in endoplasmic reticulum ;
>>Osteoclast differentiation ;
>>Tight junction ;
>>Toll-like receptor signaling pathway ;
>>T cell receptor signaling pathway ;
>>Fc epsilon RI signaling pathway ;
>>TNF signaling pathway ;
>>Neurotrophin signaling pathway ;
>>GnRH signaling pathway ;
>>Relaxin signaling pathway ;
>>Alcoholic liver disease ;
>>Alzheimer disease ;
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Salmonella infection ;
>>Yersinia infection ;
>>Hepatitis B ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Human immunodeficiency virus 1 infection ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis