Synthesized pospho peptide derived from human CaMK2 (Phospho-Thr286)

This antibody detects endogenous pospho levels of human CaMK2 (Phospho-Thr286) .The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QEtVD

CAMK2D CAMKD

CaMK2 (Phospho-Thr286)

Calcium/calmodulin-dependent protein kinase type II subunit delta ;
CaM kinase II subunit delta ;
CaMK-II subunit delta ;

The product of this gene belongs to the serine/threonine protein kinases family , and to the Ca (2+) /calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha , beta , gamma , and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM) -dependent activity , this protein can undergo autophosphorylation , resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq , Nov 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. ,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Postsynaptic lipid rafts. ,subunit:CAMK2 is composed of four different chains: alpha , beta , gamma , and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC , MPDZ , SYN1 , CAMK2N2 and SYNGAP1. ,

Cell junction , synapse . Cell junction , synapse , postsynaptic density . Cell projection , dendritic spine . Cell projection , dendrite . Postsynaptic lipid rafts. .

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