MARCKS (Phospho Ser159/163) Rabbit pAb
-YP1392
主要信息
Target
MARCKS Phospho Ser159/163
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
32kD (Observed)
Conjugate/Modification
Phospho
货号: YP1392
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:1000-2000
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser159 or Ser163,and dually phosphorylated at two sites.
纯化工艺
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
32kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
Synthesized phosho peptide around human MARCKS (Ser159 and 163)
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特异性:
This antibody detects endogenous levels of MARCKS only when phosphorylated at Ser159 or Ser163,and dually phosphorylated at two sites.
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基因名称:
MARCKS MACS PRKCSL
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蛋白名称:
MARCKS (Ser159/163)
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别名:
Myristoylated alanine-rich C-kinase substrate ;
MARCKS ;
Protein kinase C substrate, 80 kDa protein, light chain ;
80K-L protein ;
PKCSL ;
MARCKS ;
Protein kinase C substrate, 80 kDa protein, light chain ;
80K-L protein ;
PKCSL ;
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背景:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008],
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功能:
Function:MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.,PTM:Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.,similarity:Belongs to the MARCKS family.,
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细胞定位:
Cytoplasm, cytoskeleton . Membrane ; Lipid-anchor .
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组织表达:
研究领域:
>>Fc gamma R-mediated phagocytosis ;
>>MicroRNAs in cancer
>>MicroRNAs in cancer
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信号通路
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货号: YP1392
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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