PIP5KIII (Phospho Ser307) Rabbit pAb
-YP1162
主要信息
Target
PIP5K Phospho Ser307
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
237kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1162
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-PIP5KIII (S307) Polyclonal Antibody detects endogenous levels of PIP5KIII protein only when phosphorylated at S307.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SAsIT
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
237kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
相关产品
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PIP5KIII Rabbit pAb
YT3734
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Primary Antibodies
PIP5KIII (Phospho Ser307) Rabbit pAb
YP1162
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ELISA Kits
Total PIP5K Cell-Based Colorimetric ELISA Kit
KA4234C
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human PIP5K around the phosphorylation site of Ser307. AA range:273-322
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特异性:
Phospho-PIP5KIII (S307) Polyclonal Antibody detects endogenous levels of PIP5KIII protein only when phosphorylated at S307.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SAsIT
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基因名称:
PIKFYVE
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蛋白名称:
1-phosphatidylinositol 3-phosphate 5-kinase
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别名:
PIKFYVE ;
KIAA0981 ;
PIP5K3 ;
1-phosphatidylinositol 3-phosphate 5-kinase ;
Phosphatidylinositol 3-phosphate 5-kinase ;
FYVE finger-containing phosphoinositide kinase ;
PIKfyve ;
Phosphatidylinositol 3-phosphate 5-kinase type III ;
PIPkin-III ;
Type
KIAA0981 ;
PIP5K3 ;
1-phosphatidylinositol 3-phosphate 5-kinase ;
Phosphatidylinositol 3-phosphate 5-kinase ;
FYVE finger-containing phosphoinositide kinase ;
PIKfyve ;
Phosphatidylinositol 3-phosphate 5-kinase type III ;
PIPkin-III ;
Type
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背景:
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions , membrane trafficking , and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns (3 ,5) biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast , PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase , PIKf
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功能:
Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4 ,5-bisphosphate. ,Disease:Defects in PIKFYVE are the cause of corneal fleck dystrophy (CFD) [MIM:121850]. CFD is an autosomal dominant disorder of the cornea characterized by numerous small white flecks scattered in all levels of the stroma. Although CFD may occasionally cause mild photophobia , patients are typically asymptomatic and have normal vision. ,Function:Supports the intracellular PIP pool and to a lesser extent , the PI 4 ,5-P (2) pool. It generates PIP from PI and , to a lesser extent , PI 4 ,5-P (2) from PI 4-P. There are indications that it phosphorylates the D-5 rather than the D-4 position. Has a role in endosome-related membrane trafficking. ,similarity:Contains 1 DEP domain. ,similarity:Contains 1 FYVE-type zinc finger. ,similarity:Contains 1 PI5K domain. ,subcellular location:Mainly associated with membranes of the late endocytic pathway. ,
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细胞定位:
Endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein. Cytoplasmic vesicle , phagosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Mainly associated with membranes of the late endocytic pathway. .
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研究领域:
>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phagosome ;
>>Regulation of actin cytoskeleton
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phagosome ;
>>Regulation of actin cytoskeleton
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信号通路
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货号: YP1162
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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