DAPK2 (Phospho Ser318) Rabbit pAb
-YP1142
主要信息
Target
DAPK2 Phospho Ser318
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
43kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1142
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-DAPK2 (S318) Polyclonal Antibody detects endogenous levels of DAPK2 protein only when phosphorylated at S318.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KLsFS
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
43kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human DAPK2 around the phosphorylation site of Ser318. AA range:284-333
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特异性:
Phospho-DAPK2 (S318) Polyclonal Antibody detects endogenous levels of DAPK2 protein only when phosphorylated at S318.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KLsFS
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基因名称:
DAPK2
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蛋白名称:
Death-associated protein kinase 2
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别名:
DAPK2 ;
Death-associated protein kinase 2 ;
DAP kinase 2 ;
DAP-kinase-related protein 1 ;
DRP-1
Death-associated protein kinase 2 ;
DAP kinase 2 ;
DAP-kinase-related protein 1 ;
DRP-1
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背景:
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1) , a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Negatively regulated by autophosphorylation on Ser-318. ,Function:Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Homodimer. Homodimerization is required for apoptotic function and is inhibited by autophosphorylation at Ser-318. ,tissue specificity:Ubiquitously expressed in all tissue types examined. High levels in heart , lung and skeletal muscle. ,
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细胞定位:
Cytoplasm. Cytoplasmic vesicle , autophagosome lumen.
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研究领域:
>>Autophagy - animal ;
>>Pathways in cancer ;
>>Bladder cancer
>>Pathways in cancer ;
>>Bladder cancer
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信号通路
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货号: YP1142
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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