The antiserum was produced against synthesized peptide derived from human NMDAR1 around the phosphorylation site of Ser890. AA range:856-905

Phospho-NMDAR1 (S890) Polyclonal Antibody detects endogenous levels of NMDAR1 protein only when phosphorylated at S890.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):ASsFK

GRIN1

Glutamate [NMDA] receptor subunit zeta-1

GRIN1 ;
NMDAR1 ;
Glutamate [NMDA] receptor subunit zeta-1 ;
N-methyl-D-aspartate receptor subunit NR1 ;
NMD-R1

The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors , members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses , which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms , possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq , Jul 2008] ,

Function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity , synaptogenesis , excitotoxicity , memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. ,online information:NMDA receptor entry ,PTM:NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB) . Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subcellular location:Enriched in post-synaptic plasma membrane and post-synaptic densities. ,subunit:Forms heteromeric channel of a zeta subunit (GRIN1) , a epsilon subunit (GRIN2A , GRIN2B , GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B) ; disulfide-linked. Found in a complex with GRIN2A or GRIN2B , GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. ,

Cell membrane ; Multi-pass membrane protein . Cell junction , synapse , postsynaptic cell membrane . Cell junction , synapse , postsynaptic density . Enriched in postsynaptic plasma membrane and postsynaptic densities. .

>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Glutamatergic synapse ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Nicotine addiction ;
>>Alcoholism