Fhit (Phospho Tyr114) Rabbit pAb
-YP1114
主要信息
Target
Fhit Phospho Tyr114
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
17kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1114
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Fhit (Y114) Polyclonal Antibody detects endogenous levels of Fhit protein only when phosphorylated at Y114.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SIyEE
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
17kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human FHIT around the phosphorylation site of Tyr114. AA range:80-129
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特异性:
Phospho-Fhit (Y114) Polyclonal Antibody detects endogenous levels of Fhit protein only when phosphorylated at Y114.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):SIyEE
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基因名称:
FHIT
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蛋白名称:
Bis (5'-adenosyl) -triphosphatase
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别名:
FHIT ;
Bis ;
5'-adenosyl ;
-triphosphatase ;
AP3A hydrolase ;
AP3Aase ;
Diadenosine 5' ;
5'''-P1,P3-triphosphate hydrolase ;
Dinucleosidetriphosphatase ;
Fragile histidine triad protein
Bis ;
5'-adenosyl ;
-triphosphatase ;
AP3A hydrolase ;
AP3Aase ;
Diadenosine 5' ;
5'''-P1,P3-triphosphate hydrolase ;
Dinucleosidetriphosphatase ;
Fragile histidine triad protein
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背景:
This gene , a member of the histidine triad gene family , encodes a diadenosine 5' ,5'''-P1 ,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3 , where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact , aberrant transcripts from this gene have been found in about half of all esophageal , stomach , and colon carcinomas. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq , Oct 2009] ,
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功能:
Catalytic activity:P (1) -P (3) -bis (5'-adenosyl) triphosphate + H (2) O = ADP + AMP. ,cofactor:Divalent cations. Magnesium , but manganese and to a lesser extent calcium or cobalt can be substituted; but not zinc , cadmium or nickel. ,Disease:A chromosomal aberration involving FHIT is observed in early onset bilateral and multifocal clear cell renal carcinoma [MIM:144700]. Translocation t (3;8) (3p14.2) . ,Disease:Associated with digestive tract cancers. Numerous tumor types are found to have aberrant forms of FHIT protein due to deletions in a coding region of chromosome 3p14.2 including the fragile site locus FRA3B. ,Function:Cleaves A-5'-PPP-5'A to yield AMP and ADP. Possible tumor suppressor for specific tissues. ,mass spectrometry: PubMed:15007172 ,similarity:Contains 1 HIT domain. ,subunit:Homodimer. ,tissue specificity:Low levels expressed in all tissues tested. Phospho-FHIT observed in liver and kidney , but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. ,
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细胞定位:
Cytoplasm . Mitochondrion . Nucleus .
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研究领域:
>>Purine metabolism ;
>>Metabolic pathways ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer
>>Metabolic pathways ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer
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信号通路
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货号: YP1114
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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