APLP2 (Phospho Tyr755) Rabbit pAb
-YP1079
主要信息
Target
APLP2 Phospho Tyr755
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, IF, ELISA
MW
87kD (Calculated)
Conjugate/Modification
Phospho
货号: YP1079
规格
价格
货期
数量
200μL
￥4,680.00
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0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-APLP2 (Y755) Polyclonal Antibody detects endogenous levels of APLP2 protein only when phosphorylated at Y755.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PTyKY
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
理论分子量
87kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human APLP2 around the phosphorylation site of Tyr755. AA range:714-763
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特异性:
Phospho-APLP2 (Y755) Polyclonal Antibody detects endogenous levels of APLP2 protein only when phosphorylated at Y755.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PTyKY
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基因名称:
APLP2
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蛋白名称:
Amyloid-like protein 2
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别名:
APLP2 ;
APPL2 ;
Amyloid-like protein 2 ;
APLP-2 ;
APPH ;
Amyloid protein homolog ;
CDEI box-binding protein ;
CDEBP
APPL2 ;
Amyloid-like protein 2 ;
APLP-2 ;
APPH ;
Amyloid protein homolog ;
CDEI box-binding protein ;
CDEBP
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背景:
This gene encodes amyloid precursor- like protein 2 (APLP2) , which is a member of the APP (amyloid precursor protein) family including APP , APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin- , copper- and zinc- binding domains at the N-terminus , BPTI/Kunitz inhibitor and E2 domains in the middle region , and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission , spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq , Aug 2011] ,
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功能:
Alternative products:Additional isoforms seem to exist ,Function:May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3' (CDEI box) . Inhibits trypsin , chymotrypsin , plasmin , factor XIA and plasma and glandular kallikrein. ,PTM:The BPTI/Kunitz inhibitor domain is O-glycosylated. ,similarity:Belongs to the APP family. ,similarity:Contains 1 BPTI/Kunitz inhibitor domain. ,subunit:Interacts with CPEB1. ,tissue specificity:In placenta , brain , heart , lung , liver , kidney and endothelial tissues. ,
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细胞定位:
Cell membrane ; Single-pass type I membrane protein . Nucleus .
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货号: YP1079
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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