The antiserum was produced against synthesized peptide derived from human MARK1/2/3/4 around the phosphorylation site of Thr215. AA range:181-230

Phospho-MARK1/2/3/4 (T215) Polyclonal Antibody detects endogenous levels of MARK1/2/3/4 protein only when phosphorylated at T215.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LDtFC

MARK1/2/3/4

Serine/threonine-protein kinase MARK1/2/3/4

MARK1 ;
KIAA1477 ;
MARK ;
Serine/threonine-protein kinase MARK1 ;
MAP/microtubule affinity-regulating kinase 1 ;
PAR1 homolog c ;
Par-1c ;
Par1c ;
MARK2 ;
EMK1 ;
Serine/threonine-protein kinase MARK2 ;
ELKL motif kinase 1 ;
EMK-1 ;
MAP/microtubule affin

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Activated by phosphorylation on Thr-215 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. ,function:May play a role in cytoskeletal stability. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. ,similarity:Contains 1 KA1 (kinase-associated) domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 UBA domain. ,subcellular location:Appears to localize to an intracellular network. ,tissue specificity:Highly expressed in heart , skeletal muscle , brain , fetal brain and fetal kidney. ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Activated by phosphorylation on Thr-215 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. ,Function:May play a role in cytoskeletal stability. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. MARK subfamily. ,similarity:Contains 1 KA1 (kinase-associated) domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 UBA domain. ,subcellular location:Appears to localize to an intracellular network. ,tissue specificity:Highly expressed in heart , skeletal muscle , brain , fetal brain and fetal kidney. ,

Cell membrane ; Peripheral membrane protein . Cytoplasm , cytoskeleton . Cytoplasm . Cell projection , dendrite . Appears to localize to an intracellular network. .