IGFBP3 (Phospho Ser183) Rabbit pAb
-YP1001
主要信息
Target
IGFBP3 Phospho Ser183
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
31kD (Observed)
Conjugate/Modification
Phospho
货号: YP1001
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-IGFBP3 (S183) Polyclonal Antibody detects endogenous levels of IGFBP3 protein only when phosphorylated at S183.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KDsQR
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
31kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human IGFBP-3 around the phosphorylation site of Ser183. AA range:151-200
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特异性:
Phospho-IGFBP3 (S183) Polyclonal Antibody detects endogenous levels of IGFBP3 protein only when phosphorylated at S183.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KDsQR
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基因名称:
IGFBP3
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蛋白名称:
Insulin-like growth factor-binding protein 3
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别名:
IGFBP3 ;
IBP3 ;
Insulin-like growth factor-binding protein 3 ;
IBP-3 ;
IGF-binding protein 3 ;
IGFBP-3
IBP3 ;
Insulin-like growth factor-binding protein 3 ;
IBP-3 ;
IGF-binding protein 3 ;
IGFBP-3
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背景:
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form , it circulates in the plasma , prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants , encoding different isoforms , have been characterized. [provided by RefSeq , Jul 2008] ,
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功能:
developmental stage:IGFBP3 levels are higher during extrauterine life and peak during puberty. ,Domain:The thyroglobulin type-1 domain mediates interaction with HN. ,Function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. ,induction:IGFBP3 levels increase in the presence of IGF1 , insulin and other growth-stimulating factors such as growth hormone , epidermal growth factor , and phorbol esters. ,online information:The Singapore human mutation and polymorphism database ,similarity:Contains 1 IGFBP N-terminal domain. ,similarity:Contains 1 thyroglobulin type-1 domain. ,subunit:Interacts with XLKD1 (By similarity) . Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS) . Interacts with HN. ,tissue specificity:Expressed by most tissues. ,
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细胞定位:
Secreted .
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研究领域:
>>p53 signaling pathway ;
>>Cellular senescence ;
>>Growth hormone synthesis , secretion and action ;
>>Transcriptional misregulation in cancer
>>Cellular senescence ;
>>Growth hormone synthesis , secretion and action ;
>>Transcriptional misregulation in cancer
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信号通路
Cellular Processes >> Cell growth and death >> p53 signaling pathway
Cellular Processes >> Cell growth and death >> Cellular senescence
Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action
Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
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货号: YP1001
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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