The antiserum was produced against synthesized peptide derived from human Rhodopsin around the phosphorylation site of Ser334. AA range:299-348

Phospho-Rhodopsin (S334) Polyclonal Antibody detects endogenous levels of Rhodopsin protein only when phosphorylated at S334.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DAsAT

RHO

Rhodopsin

RHO ;
OPN2 ;
Rhodopsin ;
Opsin-2

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant , autosomal recessive , or X-linked recessive disorder. In the autosomal dominant form ,which comprises about 25% of total cases , approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which , when photoexcited , initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq , Jul 2008] ,

Disease:Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. ,Disease:Defects in RHO are the cause of congenital stationary night blindness autosomal dominant type 1 (CSNBAD1) [MIM:610445]; also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. ,Disease:Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4) [MIM:180380]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses , they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. ,Function:Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. ,online information:Retina International's Scientific Newsletter ,online information:Rhodopsin entry ,online information:Rhodopsin mutations page ,PTM:Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. ,similarity:Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. ,tissue specificity:Rod shaped photoreceptor cells which mediates vision in dim light. ,

Membrane ; Multi-pass membrane protein . Cell projection , cilium , photoreceptor outer segment . Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. .

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