MOR-1 (Phospho Ser375) Rabbit pAb
-YP0953
主要信息
Target
MOR-1 Phospho Ser375
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
45kD (Observed)
Conjugate/Modification
Phospho
货号: YP0953
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-MOR-1 (S375) Polyclonal Antibody detects endogenous levels of MOR-1 protein only when phosphorylated at S375.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HPsTA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
45kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Opioid Receptor around the phosphorylation site of Ser375. AA range:341-390
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特异性:
Phospho-MOR-1 (S375) Polyclonal Antibody detects endogenous levels of MOR-1 protein only when phosphorylated at S375.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HPsTA
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基因名称:
OPRM1
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蛋白名称:
Mu-type opioid receptor
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别名:
OPRM1 ;
MOR1 ;
Mu-type opioid receptor ;
M-OR-1 ;
MOR-1 ;
Mu opiate receptor ;
Mu opioid receptor ;
MOP ;
hMOP
MOR1 ;
Mu-type opioid receptor ;
M-OR-1 ;
MOR-1 ;
Mu opiate receptor ;
Mu opioid receptor ;
MOP ;
hMOP
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背景:
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR) . The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse , such as nicotine , cocaine , and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq , Oct 2013] ,
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功能:
Function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin. ,online information:Mu opioid receptor entry ,polymorphism:Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested , but it binds beta-endorphin , an endogenous opioid that activates the mu opioid receptor , approximately 3 times more tightly than the most common allelic form. ,similarity:Belongs to the G-protein coupled receptor 1 family. ,subunit:Forms a complex with G (alpha) z/i2 subunits and the RGSZ proteins , RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20. ,
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细胞定位:
Cell membrane ; Multi-pass membrane protein . Cell projection , axon . Perikaryon . Cell projection , dendrite . Endosome . Is rapidly internalized after agonist binding. .; [Isoform 12]: Cytoplasm .
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研究领域:
>>Neuroactive ligand-receptor interaction ;
>>Estrogen signaling pathway ;
>>Morphine addiction
>>Estrogen signaling pathway ;
>>Morphine addiction
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文献引用（{{totalcount}}）
货号: YP0953
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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