The antiserum was produced against synthesized peptide derived from human FANCA around the phosphorylation site of Ser1149. AA range:1121-1170

Phospho-FANCA (S1149) Polyclonal Antibody detects endogenous levels of FANCA protein only when phosphorylated at S1149.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):DPsLM

FANCA

Fanconi anemia group A protein

FANCA ;
FAA ;
FACA ;
FANCH ;
Fanconi anemia group A protein ;
Protein FACA

The Fanconi anemia complementation group (FANC) currently includes FANCA , FANCB , FANCC , FANCD1 (also called BRCA2) , FANCD2 , FANCE , FANCF , FANCG , FANCI , FANCJ (also called BRIP1) , FANCL , FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability , hypersensitivity to DNA crosslinking agents , increased chromosomal breakage , and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq , Jul

Disease:Defects in FANCA are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous , autosomal recessive disorder characterized by progressive pancytopenia , a diverse assortment of congenital malformations , and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents , chromosomal instability (increased chromosome breakage) , and defective DNA repair. ,Function:DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A , B , C , E , F , G , and H. ,subcellular location:The major form is nuclear. The minor form is cytoplasmic. ,subunit:Belongs to the multisubunit FA complex composed of FANCA , FANCB , FANCC , FANCE , FANCF , FANCG , FANCL/PHF9 and FANCM. The complex is not found in FA patients. ,

Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.

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