The antiserum was produced against synthesized peptide derived from human CaMK1-alpha around the phosphorylation site of Thr177. AA range:143-192

Phospho-CaMKIα (T177) Polyclonal Antibody detects endogenous levels of CaMKIα protein only when phosphorylated at T177.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LStAC

CAMK1

Calcium/calmodulin-dependent protein kinase type 1

CAMK1 ;
Calcium/calmodulin-dependent protein kinase type 1 ;
CaM kinase I ;
CaM-KI ;
CaM kinase I alpha ;
CaMKI-alpha

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq , Jul 2008] ,

Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Domain:The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate. ,enzyme regulation:Activated by Ca (2+) /calmodulin. Binding of calmodulin results in a conformational change that generates functional binding sites for both , substrate and ATP , and thus releaves intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2. ,Function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes like transcriptional regulation , hormone production , translational regulation , regulation of actin filament organization and neurite outgrowth. Involved in calcium-dependent activation of the ERK pathway (By similarity) . Recognizes the substrate consensus sequence [MVLIF]-x-R-x (2) -[ST]-x (3) -[MVLIF]. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1 , ATF1 , CTFR , MYL9 , SYN1/synapsin I and SYNII/synapsin II. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Predominantly cytoplasmic. ,subunit:Monomer. Interacts with XPO1. ,tissue specificity:Ubiquitous. ,

Cytoplasm . Nucleus . Predominantly cytoplasmic. .

>>Calcium signaling pathway ;
>>Oxytocin signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Glioma