Cortactin (Phospho Tyr466) Rabbit pAb
-YP0846
主要信息
Target
Cortactin Phospho Tyr466
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
80kD (Observed)
Conjugate/Modification
Phospho
货号: YP0846
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Cortactin (Y466) Polyclonal Antibody detects endogenous levels of Cortactin protein only when phosphorylated at Y466.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PVyET
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
80kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from mouse Cortactin around the phosphorylation site of Tyr466. AA range:441-490
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特异性:
Phospho-Cortactin (Y466) Polyclonal Antibody detects endogenous levels of Cortactin protein only when phosphorylated at Y466.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PVyET
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基因名称:
CTTN
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蛋白名称:
Src substrate cortactin
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别名:
CTTN ;
EMS1 ;
Src substrate cortactin ;
Amplaxin ;
Oncogene EMS1
EMS1 ;
Src substrate cortactin ;
Amplaxin ;
Oncogene EMS1
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背景:
cortactin (CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis , the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq , May 2010] ,
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功能:
Function:May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. ,online information:Cortactin entry ,similarity:Contains 1 SH3 domain. ,similarity:Contains 7 cortactin repeats. ,subcellular location:Associated with membrane ruffles and lamellipodia. ,subunit:Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity) . Interacts with PLXDC2. ,
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细胞定位:
Cytoplasm , cytoskeleton . Cell projection , lamellipodium . Cell projection , ruffle. Cell projection , dendrite . Cell projection . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , podosome . Cell junction . Cell junction , focal adhesion . Membrane , clathrin-coated pit . Cell projection , dendritic spine . Cytoplasm , cell cortex . Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity) . Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL , colocalizes with stress fibers (By similarity) . In the presence of CTTNBP2 , localizes at the cell cortex (By similarity) . In response to neuronal activation by glutamate , redistributes from dendritic spines to the dendritic shaft (By similarity) . Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity) . .
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研究领域:
>>Tight junction ;
>>Bacterial invasion of epithelial cells ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Proteoglycans in cancer
>>Bacterial invasion of epithelial cells ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Proteoglycans in cancer
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文献引用（{{totalcount}}）
货号: YP0846
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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