FRS2 (Phospho Tyr436) Rabbit pAb
-YP0805
主要信息
Target
FRS2 Phospho Tyr436
Host Species
Rabbit
Reactivity
Human, Mouse, Monkey
Applications
WB, IHC, IF, ELISA
MW
65kD (Observed)
Conjugate/Modification
Phospho
货号: YP0805
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LNyIQ
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
65kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human FRS2 around the phosphorylation site of Tyr436. AA range:402-451
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特异性:
Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):LNyIQ
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基因名称:
FRS2
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蛋白名称:
Fibroblast growth factor receptor substrate 2
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别名:
FRS2 ;
Fibroblast growth factor receptor substrate 2 ;
FGFR substrate 2 ;
FGFR-signaling adaptor SNT ;
Suc1-associated neurotrophic factor target 1 ;
SNT-1
Fibroblast growth factor receptor substrate 2 ;
FGFR substrate 2 ;
FGFR-signaling adaptor SNT ;
Suc1-associated neurotrophic factor target 1 ;
SNT-1
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背景:
function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. ,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF. ,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. ,sequence caution:Translated as stop. ,similarity:Contains 1 IRS-type PTB domain. ,subcellular location:Cytoplasmic , membrane-bound. ,subunit:Part of a complex containing FRS2 , GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity) . Binds FGFR1 , SUC1 , NTRK1 , NTRK2 , NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. ,tissue specificity:Highly expressed in heart , brain , spleen , lung , liver , skeletal muscle , kidney and testis. ,
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功能:
Function:Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. ,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF. ,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. ,sequence Caution:Translated as stop. ,similarity:Contains 1 IRS-type PTB domain. ,subcellular location:Cytoplasmic , membrane-bound. ,subunit:Part of a complex containing FRS2 , GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity) . Binds FGFR1 , SUC1 , NTRK1 , NTRK2 , NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. ,tissue specificity:Highly expressed in heart , brain , spleen , lung , liver , skeletal muscle , kidney and testis. ,
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细胞定位:
Endomembrane system. Cytoplasmic , membrane-bound.
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组织表达:
研究领域:
>>Thermogenesis ;
>>Neurotrophin signaling pathway ;
>>Proteoglycans in cancer
>>Neurotrophin signaling pathway ;
>>Proteoglycans in cancer
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文献引用（{{totalcount}}）
货号: YP0805
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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