Trk C (Phospho Tyr516) Rabbit pAb
-YP0800
主要信息
Target
Trk C Phospho Tyr516
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
90-130kd (Observed)
Conjugate/Modification
Phospho
货号: YP0800
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PQyFR
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
90-130kd
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Trk C around the phosphorylation site of Tyr516. AA range:482-531
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特异性:
Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PQyFR
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基因名称:
NTRK3
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蛋白名称:
NT-3 growth factor receptor
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别名:
NTRK3 ;
TRKC ;
NT-3 growth factor receptor ;
GP145-TrkC ;
Trk-C ;
Neurotrophic tyrosine kinase receptor type 3 ;
TrkC tyrosine kinase
TRKC ;
NT-3 growth factor receptor ;
GP145-TrkC ;
Trk-C ;
Neurotrophic tyrosine kinase receptor type 3 ;
TrkC tyrosine kinase
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背景:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that , upon neurotrophin binding , phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas , secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2011] ,
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功能:
Alternative products:Additional isoforms seem to exist ,Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Function:Receptor for neurotrophin-3 (NT-3) . This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1 , PI-3 kinase , and PLCG1. The different isoforms do not have identical signaling properties. ,PTM:Ligand-mediated auto-phosphorylation. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains. ,similarity:Contains 2 LRR (leucine-rich) repeats. ,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220. ,tissue specificity:Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain. ,
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细胞定位:
Membrane; Single-pass type I membrane protein.
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研究领域:
>>Calcium signaling pathway ;
>>Neurotrophin signaling pathway ;
>>Central carbon metabolism in cancer
>>Neurotrophin signaling pathway ;
>>Central carbon metabolism in cancer
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信号通路
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货号: YP0800
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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