MEK Kinase-1 (Phospho Thr1402) Rabbit pAb
-YP0786
主要信息
Target
MEK Kinase-1 Phospho Thr1402
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
160kD (Observed)
Conjugate/Modification
Phospho
货号: YP0786
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-MEK Kinase-1 (T1402) Polyclonal Antibody detects endogenous levels of MEK Kinase-1 protein only when phosphorylated at T1402.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KGtGA
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
160kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human MAP3K1 around the phosphorylation site of Thr1402. AA range:1368-1417
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特异性:
Phospho-MEK Kinase-1 (T1402) Polyclonal Antibody detects endogenous levels of MEK Kinase-1 protein only when phosphorylated at T1402.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KGtGA
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基因名称:
MAP3K1
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蛋白名称:
Mitogen-activated protein kinase kinase kinase 1
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别名:
MAP3K1 ;
MAPKKK1 ;
MEKK ;
MEKK1 ;
Mitogen-activated protein kinase kinase kinase 1 ;
MAPK/ERK kinase kinase 1 ;
MEK kinase 1 ;
MEKK 1
MAPKKK1 ;
MEKK ;
MEKK1 ;
Mitogen-activated protein kinase kinase kinase 1 ;
MAPK/ERK kinase kinase 1 ;
MEK kinase 1 ;
MEKK 1
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背景:
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades , including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq , Mar 2012] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization. ,Function:Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB , the central protein kinases of the NF-kappa-B pathway. ,PTM:Autophosphorylated. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 RING-type zinc finger. ,similarity:Contains 1 SWIM-type zinc finger. ,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. ,
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细胞定位:
cytoplasm ,cytosol ,
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组织表达:
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研究领域:
>>MAPK signaling pathway ;
>>Ubiquitin mediated proteolysis ;
>>Tight junction ;
>>RIG-I-like receptor signaling pathway ;
>>Neurotrophin signaling pathway ;
>>GnRH signaling pathway ;
>>Growth hormone synthesis , secretion and action ;
>>Hepatitis B ;
>>Human T-cell leukemia virus 1 infection
>>Ubiquitin mediated proteolysis ;
>>Tight junction ;
>>RIG-I-like receptor signaling pathway ;
>>Neurotrophin signaling pathway ;
>>GnRH signaling pathway ;
>>Growth hormone synthesis , secretion and action ;
>>Hepatitis B ;
>>Human T-cell leukemia virus 1 infection
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信号通路
Cellular Processes >> Cellular community - eukaryotes >> Tight junction
Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway
Organismal Systems >> Endocrine system >> GnRH signaling pathway
Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis
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货号: YP0786
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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