Moesin/Ezrin/Radixin (Phospho Thr558) Rabbit pAb
-YP0940
主要信息
Target
Moesin/Ezrin/Radixin Phospho Thr558
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
67kD (Observed)
Conjugate/Modification
Phospho
货号: YP0940
规格
价格
货期
数量
200μL
￥4,680.00
一个月
0
100μL
￥2,800.00
一个月
0
50μL
￥1,500.00
一个月
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Moesin/Ezrin/Radixin (T558) Polyclonal Antibody detects endogenous levels of Moesin/Ezrin/Radixin protein only when phosphorylated at T558.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YKtLR
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
浓度
1 mg/ml
实测条带
67kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Moesin/Ezrin/Radixin around the phosphorylation site of Thr558. AA range:524-573
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特异性:
Phospho-Moesin/Ezrin/Radixin (T558) Polyclonal Antibody detects endogenous levels of Moesin/Ezrin/Radixin protein only when phosphorylated at T558.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YKtLR
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基因名称:
MSN
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蛋白名称:
Moesin
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别名:
MSN ;
Moesin ;
Membrane-organizing extension spike protein ;
RDX ;
Radixin ;
EZR ;
VIL2 ;
Ezrin ;
Cytovillin ;
Villin-2 ;
p81
Moesin ;
Membrane-organizing extension spike protein ;
RDX ;
Radixin ;
EZR ;
VIL2 ;
Ezrin ;
Cytovillin ;
Villin-2 ;
p81
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数据库链接:
背景:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008],
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功能:
Function:Probably involved in connections of major cytoskeletal structures to the plasma membrane.,PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.,similarity:Contains 1 FERM domain.,subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane.,subunit:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1.,tissue specificity:In all tissues and cultured cells studied.,
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细胞定位:
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, microvillus . Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts. .
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组织表达:
研究领域:
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Measles ;
>>Proteoglycans in cancer
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Measles ;
>>Proteoglycans in cancer
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信号通路
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货号: YP0940
规格
价格
货期
数量
200μL
￥4,680.00
一个月
0
100μL
￥2,800.00
一个月
0
50μL
￥1,500.00
一个月
0
加入购物车
已收藏
收藏
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