GRK 1 (Phospho Ser21) Rabbit pAb
-YP0741
主要信息
Target
GRK1 Phospho Ser21
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
63kD (Observed)
Conjugate/Modification
Phospho
货号: YP0741
规格
价格
货期
数量
200μL
￥4,680.00
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0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-GRK 1 (S21) Polyclonal Antibody detects endogenous levels of GRK 1 protein only when phosphorylated at S21.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGsFD
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
63kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human GRK1 around the phosphorylation site of Ser21. AA range:6-55
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特异性:
Phospho-GRK 1 (S21) Polyclonal Antibody detects endogenous levels of GRK 1 protein only when phosphorylated at S21.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RGsFD
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基因名称:
GRK1
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蛋白名称:
Rhodopsin kinase
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别名:
GRK1 ;
RHOK ;
Rhodopsin kinase ;
RK ;
G protein-coupled receptor kinase 1
RHOK ;
Rhodopsin kinase ;
RK ;
G protein-coupled receptor kinase 1
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背景:
This gene encodes a member of the guanine nucleotide-binding protein (G protein) -coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2) . [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + [rhodopsin] = ADP + [rhodopsin] phosphate. ,Disease:Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation. ,Function:Phosphorylates rhodopsin thereby initiating its deactivation. ,online information:Retina International's Scientific Newsletter ,PTM:Autophosphorylated. ,PTM:Farnesylation is required for full activity. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 RGS domain. ,tissue specificity:Retina and pineal gland. ,
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细胞定位:
Membrane ; Lipid-anchor . Cell projection , cilium , photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. .
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研究领域:
>>Chemokine signaling pathway ;
>>Endocytosis ;
>>Phototransduction
>>Endocytosis ;
>>Phototransduction
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货号: YP0741
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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