The antiserum was produced against synthesized peptide derived from human GluR4 around the phosphorylation site of Ser862. AA range:828-877

Phospho-GluR4 (S862) Polyclonal Antibody detects endogenous levels of GluR4 protein only when phosphorylated at S862.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RLsIT

GRIA4

Glutamate receptor 4

GRIA4 ;
GLUR4 ;
Glutamate receptor 4 ;
GluR-4 ;
GluR4 ;
AMPA-selective glutamate receptor 4 ;
GluR-D ;
Glutamate receptor ionotropic ;
AMPA 4 ;
GluA4

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits , arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) -sensitive glutamate receptors , and is subject to RNA editing (AGA->GGA; R->G) . Alternative splicing of this gene results in transcript variants encoding different isoforms , which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq , Jul 2008] ,

Function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change , leading to the opening of the cation channel , and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state , characterized by the presence of bound agonist. ,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. ,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast , Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus. ,

Cell membrane; Multi-pass membrane protein. Cell junction , synapse , postsynaptic cell membrane; Multi-pass membrane protein. Cell projection , dendrite. Interaction with CNIH2 , CNIH3 and PRKCG promotes cell surface expression. .

>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Circadian entrainment ;
>>Retrograde endocannabinoid signaling ;
>>Glutamatergic synapse ;
>>Dopaminergic synapse ;
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Amphetamine addiction ;
>>Nicotine addiction