Dematin (Phospho Ser403) Rabbit pAb
-YP0737
主要信息
Target
Dematin Phospho Ser403
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
55kD (Observed)
Conjugate/Modification
Phospho
货号: YP0737
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
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详细信息
推荐稀释比
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
组成
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
特异性
Phospho-Dematin (S403) Polyclonal Antibody detects endogenous levels of Dematin protein only when phosphorylated at S403.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KAsLF
纯化工艺
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
浓度
1 mg/ml
实测条带
55kD
修饰
Phospho
克隆性
Polyclonal
同种型
IgG
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抗原&靶点信息
免疫原:
The antiserum was produced against synthesized peptide derived from human Dematin around the phosphorylation site of Ser403. AA range:356-405
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特异性:
Phospho-Dematin (S403) Polyclonal Antibody detects endogenous levels of Dematin protein only when phosphorylated at S403.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):KAsLF
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基因名称:
EPB49
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蛋白名称:
Dematin
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别名:
EPB49 ;
DMT ;
Dematin ;
Erythrocyte membrane protein band 4.9
DMT ;
Dematin ;
Erythrocyte membrane protein band 4.9
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背景:
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes , by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus , and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes , this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region , where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease , while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding di
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功能:
Domain:Consists of a large core fragment , the amino-terminal portion , and a small headpiece , the C-terminal portion. The headpiece can bind but cannot bundle actin filaments. ,Domain:Contains at least two actin-binding sites , one in the headpiece domain and one in the amino-terminal portion. ,Function:Actin-bundling protein. May function in mitogen-activated protein kinase pathway. ,PTM:Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase. ,PTM:The N-terminus is blocked. ,similarity:Belongs to the villin/gelsolin family. ,similarity:Contains 1 HP (headpiece) domain. ,subunit:Exists in solution as a trimer of two short isoforms and one long isoform linked by disulfide bonds (Probable) . Interacts with RASGRF2. ,tissue specificity:Heart , brain , lung , skeletal muscle , and kidney. ,
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细胞定位:
Cytoplasm. Cytoplasm , cytosol. Cytoplasm , perinuclear region . Cytoplasm , cytoskeleton. Cell membrane. Membrane . Endomembrane system. Cell projection . Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.
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货号: YP0737
规格
价格
货期
数量
200μL
￥4,680.00
现货
0
100μL
￥2,800.00
现货
0
50μL
￥1,500.00
现货
0
加入购物车
已收藏
收藏
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