The antiserum was produced against synthesized peptide derived from human CD71/TfR around the phosphorylation site of Ser24. AA range:15-64

Phospho-CD71 (S24) Polyclonal Antibody detects endogenous levels of CD71 protein only when phosphorylated at S24.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):RFsLA

TFRC

Transferrin receptor protein 1

TFRC ;
Transferrin receptor protein 1 ;
TR ;
TfR ;
TfR1 ;
Trfr ;
T9 ;
p90 ;
CD antigen CD71

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq , Sep 2015] ,

Function:Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand , the heditary hemochromatosis protein HFE , competes for binding with transferrin for an overlapping C-terminal binding site. ,induction:Regulated by cellular iron levels through binding of the iron regulatory proteins , IRP1 and IRP2 , to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. ,miscellaneous:Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells. ,miscellaneous:Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis , pregnancy , irritable bowel syndrome and in HIV patients. ,PTM:N- and O-glycosylated , phosphorylated and palmitoylated. The serum form is only glycosylated. ,PTM:Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. ,PTM:Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR) . ,similarity:Belongs to the peptidase M28 family. M28B subfamily. ,similarity:Contains 1 PA (protease associated) domain. ,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV. ,subunit:Homodimer; disulfide-linked. Binds one transferrin or HFE molecule per subunit. Binds the HLA class II histocompatibility antigen , DR1. Interacts with SH3BP3. Interacts with Machupo arenavirus GPC. ,

Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .; [Transferrin receptor protein 1 , serum form]: Secreted .

>>HIF-1 signaling pathway ;
>>Endocytosis ;
>>Phagosome ;
>>Ferroptosis ;
>>Hematopoietic cell lineage